Pharmacokinetics

This book is based on a course in Basic Pharmacokinetics and a graduate level Pharmacokinetics course.

Chapters include:

Introduction
Background Mathematics
One Compartment IV Bolus
Analysis of Urine Data
Intravenous Infusion
Routes of Drug Administration
Pharmacokinetics of Oral Administration
Calculation of Bioavailability Parameters
Bioavailability Studies
Physiological Factors Affecting Oral Absorption
Physical-Chemical Factors Affecting Oral Absorption
Formulation Factors
Multiple IV Bolus Dose Administration
Multiple Oral Dose Administration
Excretion
Metabolism
Drug Distribution
Multi-Compartment Pharmacokinetic Models
Noncompartmental Analysis
Non-Linear Pharmacokinetic Models
Pharmacodynamic and Physiologically Based Pharmacokinetic Models
Pharmaceutical Analysis
Clinical Applications of Pharmacokinetics
Non-Linear Regression Analysis of Pharmacokinetic Data
Integrating Differential Equations using Laplace Transforms
Numerical Integration
Optimization
Weighting Data
Selection of the "Best" Model
Identifiability
Optimal Sampling